The Israeli military announced an airstrike early Saturday morning on two centrifuge production sites in Isfahan, Iran, marking Israel's second attack in the area and specifically targeting Iran's nuclear program. An anonymous Israeli military official stated that these operations aim to dismantle Iran's uranium enrichment capabilities. While Isfahan's deputy governor admitted damage to the facilities, he claimed there were no casualties.

At the same time, Iranian media reported that an attack on a four-story residential building in Qom resulted in at least two deaths, with one of the deceased identified as the commander of Iran's Quds Force's Palestinian Brigade, associated with the Hamas attacks. Israel's Defense Minister termed the operation a significant achievement for intelligence and the air force.

Iran's Foreign Minister warned that any U.S. military involvement would be extremely dangerous, while Iran launched a new round of missiles and drones against Israel, most of which were intercepted by Israeli defense systems. The military estimates that over 50% of Iran's missile launchers have been destroyed. The Iranian death toll since the conflict began has surpassed 430.

The International Atomic Energy Agency issued warnings regarding potential attacks on Iran's Bushehr nuclear power plant, indicating severe radioactive leakage could ensue if directly struck. Meanwhile, diplomatic negotiations remain stalled as President Trump considers potential U.S. intervention in the war.